Zhiliang Gu, Ph.D.
Professor
School of Biology and Food Engineering
E-mail: zhilianggu88@hotmail.com
Education
Ph.D. June 2002 Animal Genetics, Breeding and Reproduction, Northest Agricultural University, Harbin, China
M.S. July 1992 Animal Genetics and Breeding, Jiangsu Agricultural college, Yangzhou, China
B.S. July 1989 Animal Science, Jiangsu Agricultural college, Yangzhou, China
Professional Experience
7/2013-1/2014 Visiting Scholar APSC, Virginia Tech, Blacksburg, VA, USA
7/2009−present Professor, Changshu Institute of Technology, Changshu
1/2006-5/2008 Postdoctoral Fellow, APSC, Virginia Tech, Blacksburg, VA, USA
4/2003−12/2005 Postdoctoral Fellow, State Key Laboratory on Agrobiotechnology， China Agricultural University, Beijing
7/2003−7/2009 Associate Professor, Changshu Institute of Technology, Changshu
6/1997−7/2003 Lecturer, Changshu Institute of Technology, Changshu
9/1995-3/1996 Visiting Research fellow, Department of Animal Genetics and Breeding, Wageningen Agricultural University, Wageningen, Netherlands
7/1992−6/1997 Research Associate, Province key Laboratory of Poultry Genetics and Breeding, Jiangsu Province Institute of Poultry Science, Yangzhou
Research Fields
Growth and developmental biology; genomics and functional genomics; miRNA; gene regulation; lipid metabolism; animal genetics and breeding; molecular evolution
Competitive Grants (selected)
Natural science foundation of Jiangsu province (No. BK20191476), “Mechanism of RNA demethylase FTO on lipid metabolism and lipid deposition in chicken liver cells”, 7/1/2019-6/30/2022. Role: PI
National Natural Science Foundation of China (No. 31772593), “Molecular mechanism of regulation of Vanin-1 gene expression and its functions in hepatic lipid metabolism in chicken”, 1/1/2018-12/31/2021. Role: PI
Natural science foundation of Jiangsu province (No. BK20151257), “Study on the molecular mechanism of MicroRNA regulating the expression of chicken SIRT1 gene”, 7/1/2015-6/30/2018. Role: PI
National Natural Science Foundation of China (No. 31472091), “Regulation of SIRT1 gene expressiong and it’s role in hepatic lipid metabolism in chicken”, 1/1/2015-12/31/2018. Role: PI
National Natural Science Foundation of China (No. 31272438), “Expressional Regulation of miR-122 and its Role in Hepatic Lipid Metabolism in Chicken” , 1/1/2013-12/31/2016. Role: PI
National Natural Science Foundation of China (No. 31072025) “Mechanism of GH regulation of IGF-I gene expression in chicken”, 1/1/2011-12/31/2013. Role: PI
National Natural Science Foundation of China (No. 30871789) “Identification, characterization and function of microRNA from the chicken adipose tissue and skeletal muscle” 1/1/2009-12/31/2011. Role: PI
The Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry(20111139)， “The complete sequences of mitochondrial genomes of Elopichthysbambusa (Richardson) and Spualiobarbus Curriculus and their evolutionary relationship” 9/1/2011-12/31/2013. Role: PI
Natural science foundation of Jiangsu province (No. BK2005026), “Molecular cloning and function of adiponectin gene in duck”, 7/1/2005-12/31/2008. Role: PI
Natural science foundation of Jiangsu province (No. BK2004055), “Molecular cloning and polymorphisms of FABP gene in duck”, 7/1/2004-12/31/2007. Role: Co-PI
Peer-Reviewed Journal Publications (selected)
(Papers are listed in chronological order; ‡ indicates the corresponding author)
Shao Fang, Wang Xingguo, Yu Jianfeng, Sheng Kai, Qi Chunjian, Gu Zhiliang‡, Expression of miR-33 from an SREBP2 Intron Inhibits the Expression of the Fatty Acid Oxidation-Regulatory Genes CROT and HADHB in Chicken Liver. British Poultry Science, 2019, 60(2):115–124
Wang xingguo, Yu Jiangfeng, Shao Fang, Zhang Yanping, Li Yanyan, Lu Xiangyun, Gong Daoqing, Gu Zhiliang‡, microRNA-122 Targets the P4HA1 mRNA and Regulates its Expression in Chicken Hepatocytes. Italian Journal of Animal Science, 2019, 18(1): 587–593
Li Yanyan #, Wang Xingguo#, Yu Jianfeng, Shao Fang, Zhang Yanping, Lu Xiangyun, Gu Zhiliang ‡, MiR-122 targets the vanin 1 gene to regulate its expression in chickens. Poultry Science, 2016, 95 (5): 1145-1150.
Wang Xingguo, Shao Fang, Yu Jianfeng, Jiang Honglin, Gong Daoqing‡, Gu Zhiliang‡, microRNA-122 Targets Genes Related to Liver Metabolism in Chickens. Comparative Biochemistry and Physiology, Part B, 2015, 184: 29-35
Wang Xingguo#, Yang Lei#, Wang Huijuan, Shao Fang, Yu JianFeng, Jiang Honglin, Han Yaoping, Gong Daoqing, Gu Zhiliang‡, Growth hormone-regulated mRNAs and miRNAs in chicken hepatocytes. PLoS ONE, 2014, 9(11): e112896.
Shao Fang, Wang Xingguo, Yu Jianfeng, Jiang Honglin, Zhu Bin, Gu Zhiliang‡, Expression of miR-33 from anSREBF2 Intron Targets the FTO Gene in the Chicken. PLoS ONE, 2014, 9(3):e91236.
Wang Xingguo, Gu Zhiliang‡, Jiang Honglin‡, MicroRNAs in farm animals, Animal. 2013, 7(10): 1567-1575
Wang Xing-Guo, Shao Fang, Wang Hui-Juan, Yang Lei, Yu Jian-Feng, Gong Dao-Qing, Gu Zhi-Liang‡, miR-126 is decreased in cultured primary chicken hepatocytes and represses Spred1, Poultry Science, 2013, 92: 1888-1896
Wang Xingguo, Shao Fang, Gong Daoqing, Lu Xiangyun, Gu Zhiliang‡. miR-133a targets to regulate birc5 gene expression in chicken. Scientia Agricultura Sinica, 2013, 46(7):1441-1447
Wang Xingguo, Yu Jianfeng, Zhang Ying, Gong Daoqing, Gu Zhiliang ‡. Identification and characterization of microRNA from chicken adipose tissue and skeletal muscle. Poultry Science, 2012, 91: 139-149.
Greger Larson, Ranran Liu, Xingbo Zhao, Jing Yuan, Dorian Fuller, Loukas Barton, Keith Dobney, Qipeng Fan, Zhiliang Gu, Xiaohui Liu, Yunbing Luo, Peng Lv, Leif Andersson, Ning Li‡. Patterns of East Asian pig domestication, migration, and turnover revealed by modern and ancient DNA. Proc Natl Acad Sci USA, 2010, 107(17): 7686–7691.
Xue Maoyun, Dong Biao, Zhang Ying, Yu Jianfeng, Meng He, Gong Daoqing, GU Zhiliang‡. Identification and prokaryotic expression of adiponectin gene in duck. Acta Veterinaria et Zootechnica Sinica, 2010, 41(10):1232-1239.
Zhang Y, Yu JF, Yang L, Wang XG, Gu Zhi Liang‡. Cloning and characterization of Caveolin-1 gene in pigeon, Columba livia domestica. Zoological Research, 2010, 31(5): 476-82.
Yu Jianfeng, Zhang Ying, Wang Xingguo, Xu Jianrong, Lu Xiangyun, Li Jianlin, Gu Zhiliang‡. Cloning and tissure expression analysis of the myostatin gene in Elopichthys bambusa. Journal of Fisheries of China, 2010, 34(10):1486-1494.
Lu XY, Zhang Y, Wang XG, Zhang YP, Xu JR, Lai R, Gu Zhi Liang‡. Identification and characterization of myostatin gene in rough-skinned sculp, Trachidermus fasciatus. Zoological Research, 2010, 31(4): 387-94.
Wang A, Gu Zhiliang, B. heid R, M. Akers, Jiang H‡. Identification and characterization of the bovine G protein-coupled receptor GPR41 and GPR43 genes. Journal of Dairy Science, 2009, 92(6): 2696-705.
Feng J, Gu Zhiliang, Wu M, Gwazdauskas, F C, Jiang H‡. Growth hormone stimulation of serum insulin concentration in cattle: nutritional dependency and potential mechanisms. Domestic Animal Endocriology. 2009, 37(2): 84-92,.
Eleswarapu Satyanaryana, Gu Zhiliang, Jiang Honglin*. Growth hormone regulation of igf-i gene expression may be mediated by multiple distal stat5 binding sites. Endocrinology, 2008, 149(5): 2230- 2240.
Gu Zhiliang, Lu Xiangyun, Zhu dahai, Li Hui, Characterization of 5’-Regulation and expressional distribution of myostatin gene in goose, Acta Veterinaria et Zootechnica Sinica, 2008, 39(11): 1606-1611.
Gu Zhiliang, Zhao Xingbo, Li Ning ‡, Changxin Wu, Complete sequence of the yak (Bos grunniens) mitochondrial genome and its evolutionary relationship with other ruminants. Molecular Phylogenetics and Evolution, 2007, 42: 248–255.
Gu Zhiliang, Eleswarapu Satyanaryana, Jiang Honglin ‡, Identification and characterization of microRNAs from the bovine adipose tissue and mammary gland. FEBS Letter, 2007, 581: 981–988.
Honglin Jiang‡, Ying Wang, Miaozong Wu, Zhiliang Gu, Stuart J. Frank and Roberto Torres-Diaz，Growth hormone stimulates hepatic expression of bovine growth hormone receptor mRNA through STAT5-activation of a major growth hormone receptor gene promoter, Endocrinology, 2007, 148(7):3307–3315.
Gu Zhiliang，Zhang Yong，Shi Peng，Zhang Ya-Ping，Zhu Dahai ‡，and Li Hui，Comparison of avian myostatin genes. Animal Genetics, 2004, 35(6), 470-472.
Gu Zhiliang, Zhu Daha‡, Li Ning, Li Hui, Deng Xuemei, Wu Changxin. The single nucleotide polymorphisms of the chicken myostatin gene are associated with skeletal muscle and adipose growth. Science in China (Ser. C Life Sciences) , 2004, 47(1): 26-31.
Gu Zhiliang , Zhang Yong, Zhu Dahai‡, Li Hui. Progress on the chicken genome project. Prog. Biochem Biophys, 2002, 3: 386-389.
